Notice
This song sounds in the key of F but was actually played in E with either the guitars and bass tuned up a half-step or the guitar master tape sped up.
Don't be afraid to show some aggression with this rhythm part; it's asking for it. You'll probably notice that when you play the A/B and Eb/B chords with your amp turned up, the guitar has to be perfectly in tune or else you'll make a bad smell. Maybe you've noticed that certain intervals in chords, when played with distortion, react negatively even when in tune. This relates to the overtone series and how it's natural properties are affected by distortion. Almost any chords besides basic triads or root and fifth power chords cause different degrees of harmonic distortion at loud volumes. Because the voicings in this song are a bit uncommon, be careful.
The solo isn't as scary as it sounds (or looks). You've got some very fast riffs to contend with, but they are all within easy reach and are repetitive figures. Work them up to speed by starting at turtle speed until you can slug it out with Moore. On the slide solo, an obvious ode to Jeff Beck, strive for a fat, lyrical sound with your neck position pickup.
Riff A is a nice idea that can be used for any major chord. This riff outlines the chords F# - E repeatedly. If you haven't already, I suggest you invest a serious effort in memorizing all of the major triads (F,A,C - F#, A#, C#, etc.),simultaneously learning all the notes on at least the E and A strings.